Cough syrup should consequently not be utilized until two weeks after the conclude of therapy with MAO inhibitors. With simultaneous consumption of analgesics (e.B. acetylsalicylic acid or paracetamol) the analgesic result of these substances may possibly mutually fortify.
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givosiran will raise the stage read more or effect of codeine by impacting hepatic enzyme CYP2D6 metabolism. Stay away from or Use Alternate Drug. Stay away from coadministration of delicate CYP2D6 substrates with givosiran. If unavoidable, lessen the CYP2D6 substrate dosage in accordance with authorised item labeling.
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diazepam buccal and codeine both raise sedation. Keep away from or Use Alternate Drug. Restrict use to sufferers for whom different treatment alternatives are inadequate
clobazam decreases effects of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Helps prevent conversion of codeine to its Energetic metabolite morphine.
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Codeine is contraindicated in sufferers who're identified to become ultrafast CYP2D6 metabolisers: Codeine is converted in its Lively metabolite morphine from the hepatic isoenzymes CYP2D6, many of which exist with genetic click here polymorphisms.
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